Vitamin D Effect on Ultrasonography and Laboratory Indices and Biochemical Indicators in the Blood: an Interventional Study on 12 to 18-Year-Old Children with Fatty Liver / 대한소아소화기영양학회지

Purpose@#The rising prevalence of childhood obesity in the past decades has caused nonalcoholic fatty liver disease (NAFLD) to become the most common cause of pediatric chronic liver disease worldwide. This study was aimed at determining the effect of vitamin D (Vit D) on ultrasonography and laboratory indices of NAFLD and some blood biochemical indicators in children. @*Methods@#In this interventional study liver ultrasonography was performed in 200 children with overweight and obesity. A 108 had fatty liver among which 101 were randomly divided into two groups of study (n=51) and control (n=50). The study group was treated with Vit D, 50000 U once a week whereas the control group received placebo with the same dose and package, both for 12 weeks. At the end of the intervention lab tests and ultrasound study was performed once again to evaluate the response to treatment. @*Results@#It was found out that Vit D supplementation improved the fatty liver grade in the study group. The mean changes in hemoglobin (Hb), uric acid, highdensity lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), insulin, albumin and alanine aminotransferase (ALT) was significantly higher in the study group compared to controls (p<0.05). After the intervention and means adjustment, a significant difference was obtained in HDL-C, insulin, LDL-C and homeostasis model assessment of insulin resistance (HOMA-IR) between the two groups. @*Conclusion@#Vit D supplementation in addition to improving the fatty liver grade in ultrasonography and increasing the blood Vit D level, increases the HDL and Hb level besides decreasing uric acid, LDL, HOMA-IR, insulin and ALT levels.

Vitamin D Effect on Ultrasonography and Laboratory Indices and Biochemical Indicators in the Blood: an Interventional Study on 12 to 18-Year-Old Children with Fatty Liver / 대한소아소화기영양학회지

Purpose@#The rising prevalence of childhood obesity in the past decades has caused nonalcoholic fatty liver disease (NAFLD) to become the most common cause of pediatric chronic liver disease worldwide. This study was aimed at determining the effect of vitamin D (Vit D) on ultrasonography and laboratory indices of NAFLD and some blood biochemical indicators in children. @*Methods@#In this interventional study liver ultrasonography was performed in 200 children with overweight and obesity. A 108 had fatty liver among which 101 were randomly divided into two groups of study (n=51) and control (n=50). The study group was treated with Vit D, 50000 U once a week whereas the control group received placebo with the same dose and package, both for 12 weeks. At the end of the intervention lab tests and ultrasound study was performed once again to evaluate the response to treatment. @*Results@#It was found out that Vit D supplementation improved the fatty liver grade in the study group. The mean changes in hemoglobin (Hb), uric acid, highdensity lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), insulin, albumin and alanine aminotransferase (ALT) was significantly higher in the study group compared to controls (p<0.05). After the intervention and means adjustment, a significant difference was obtained in HDL-C, insulin, LDL-C and homeostasis model assessment of insulin resistance (HOMA-IR) between the two groups. @*Conclusion@#Vit D supplementation in addition to improving the fatty liver grade in ultrasonography and increasing the blood Vit D level, increases the HDL and Hb level besides decreasing uric acid, LDL, HOMA-IR, insulin and ALT levels.

Association of serum levels of vascular endothelial growth factor and thrombospondin-1 to body mass index in polycystic ovary syndrome: a case-control study

PURPOSE: Polycystic ovary syndrome (PCOS) is a gynecological endocrine disorder that is characterized by disturbances in ovarian blood flow and angiogenesis. The aim of this study was to determine the association of vascular endothelial growth factor (VEGF) and thrombospondin-1 (TSP-1) serum levels with the body mass index (BMI) in patients with PCOS compared with healthy subjects. METHODS: The study was conducted with 80 subjects in 3 PCOS groups, including normal weight, overweight, and obese PCOS groups, and a control group of healthy subjects (n=20). The participants in all groups completed a questionnaire comprising sociodemographic and obstetric questions. The PCOS diagnosis in the study subjects was confirmed based on the Rotterdam criteria, BMI was determined according to the World Health Organization guidelines, and the lipid accumulation product index was calculated for all groups. Venous blood samples were collected from all participants after fasting to measure the serum levels of fasting blood glucose (FBG), lipids, insulin, VEGF, TSP-1, and leptin. RESULTS: Our findings showed that the serum VEGF level was significantly higher in the normal BMI PCOS group than that in the control group (P=0.03), and the TSP-1 level was significantly lower in the obese PCOS group than that in the control group (P=0.04). CONCLUSIONS: Our study demonstrated that alterations in VEGF and TSP-1 concentrations are dependent on BMI. Because abnormal ovarian angiogenesis is considered to be the main feature of PCOS, the study of ovarian angiogenic imbalance is proposed as a new tool for PCOS diagnosis and management.

[Effects of Jujuba essential oil on hair follicle of the skin of Balb/c mice]

Background and Aim: This study was to evaluate the effects of different concentrations of jujube seed oil on the hair follicle in BALB/c mice

Materials and Methods: In this experimental study, 40 male BALB/c mice [2.5 months of age] were used. A 4 cm[2] of the back of animal's body shaved with wax. The mice were then divided into five groups [n=8]. The first three groups received Jujube oil concentrations 5%, 10% and 15%, respectively. The fourth and fifth groups were selected as the base and sham control groups, respectively. The animals received topical treatment of jujuba seed oil for 12 day. Base and control groups received Ocerin and water respectively. After passing 12 day, back skin of animals was shaved again by wax and the treatment was repeated again for further 12 days. At 13[th] day the animals were sacrificed and samples were collected and tissue processing and staining were performed. Data were analyzed by the ANOVA and Tukey statistical tests with the 22[th] version of SPSS software

Results: This study showed that mean number of hair follicles in the skin of 5% jujuba essence treated group [37.75+/-6.6], 10% jujuba [42.75+/-8.3], 15% jujuba [41.25+/-6.2] was meaningful higher than the base [18.50+/-3.1] and sham [15+/-2.1] groups. Furthermore, we also showed that the number of hair papilla, fibroblast cells and collagen fibers were increased in the treatment groups as compared with the control groups

Conclusion: Based on our study, Jujube essential oil can have very positive effects on improving hair growth and can be used for hair losing clinical trial

[Effects of hydro alcoholic extract of internal septum of walnut on diabetic nephropathy in rats]

Background and Aim: Due to the rapid growth of global interest in use of herbal medicine, their efficacy and safety evaluation have become important. In recent studies, internal septum of walnut fruit suggested as a hypoglycemic agent. Therefore, the present work was conducted to evaluate the effects of ethanolic extract of internal septum of walnut fruit [ISWF] on some biochemical and pathological aspects related to renal function in diabetic rats

Materials and Methods: In this experimental research 32 acute Alloxan induced diabetic and 8 healthy rats divided into 5 equal group and treated orally once per day for 1 month as fallow diabetic groups I and II received 200 and 400 mg/kg of ISWF extracts, diabetic group III received 50 mg/kg metformin and diabetic group IV and healthy group received saline 0.9% as control groups. Finaly, fasting blood glucose [FBG], 24h urine total protein [UTP], blood nitrogen urea [BUN] and plasma cratinine [Cr] were assessed biochemically and also quantitative and qualitative renal histopathological altrations for 1200 glomerulus were determined pathologically

Results: In compare to diabetic control group, the ethanolic extract of ISWF in dose independence manner significantly reduced [p

Conclusion: The ethanolic extracts of ISWF have beneficial effects on renal function in diabetic rats

relationship between serum lipids and obesity among elementary school in Birjand: a case control study

Childhood obesity could induce some risk factors for cardiovascular disease [CVD] including serum lipid abnormalities, hypertension, and atherosclerosis. The present study aimed to comparison the lipid profile in normal children with cases having overweight, obesity and central obesity. In this case control study, which was conducted 2013, serum lipids for three groups of children including cases with overweight [Body mass index [BMI]: 85-95th percentiles to age and sex and waist circumference [WC] <90th percentile to age and sex = Case group1], central obesity without general obesity [BMI <85th percentiles and WC >/= percentile 90 = Case group 2] and central obesity with general obesity [BMI >/=95th percentile and WC >/= percentile 90 = Case group 3] were compared with control group [BMI < 85th percentiles WC <90th percentile]. Data were analyzed using software SPSS-16 by chi-square and ANOVA tests at significance level alpha =0.05. Each group consisted of 100 individuals. The highest mean of serum lipids and the highest extent of dyslipidemia existed in the children having central obesity along with general obesity. So that 49%, 28%, and 38% students of this group show hypertriglyceridemia, hypercholesterolemia, and low high-density lipoprotein cholesterol [HDL-C]. Odd ratio of hypertriglyceridemia, hypercholesterolemia and low HDL-c, in children with at least one abnormal index [BMI and /or WC] compared with control group were 3.73 [95% CI: 1.98, 6.99], 1.37 [95% CI: 0.71, 2.65] and 2.98 [95% CI: 1.51, 5.87], respectively. With regard to the relationship between central obesity and adverse changes in lipid profiles, the screening children for central obesity to prevention of cardiovascular disease are recommended

Cardiovascular Risk Factors: a Study on the Prevalence of MS among 11-18 Years Old School Children in East of Iran, 2012

Metabolic syndrome [MS] is associated with increased risk of cardiovascular disorders. MS is increasing among adolescents. This study was conducted to determine the prevalence of MS in 11-18 years old Birjandi school children in 2012. This cross–sectional study was conducted on 2394 eleven-eighteen years old school children in Birjand [1304 girls and 1090 boys] through Multiple-Cluster Sampling. Height, weight, waist circumference and blood pressure were measured by standard methods. Blood glucose, triglycerides, cholesterol, HDL-C and LDL-C were measured after a 12-hour fasting. MS was defined according to the modified Adult Treatment Panel III criteria. Data were analyzed by the SPSS software [ver. 16] using statistical T test, logistic regression and Chi square at P<0.05. According to this study, 6.9% of adolescents [4.5% of females and 9.9% of males] had MS. Occurrence rate of MS in male students was 2.32 times of female ones. Components of MS included low HDL [27.7%], hypertriglyceridemia [23.7%], central obesity [16.2%], systolic hypertension [9.4%], diastolic hypertension [0.9%], and high FBS [0.6%]. This study showed a significant relationship between MS, and overweight, obesity and central obesity. 48.5% of the adolescents had at least one component of MS. MS has a high prevalence in Birjandi adolescents, particularly in the obese ones. Thus, preventive measures such as correcting life style, having appropriate nutrition, and encouraging adolescents to have more physical activity are recommended

Comparison of the who child growth standards and the nchs for estimation malnutrition in Birjand-Iran

Anthropometric indices are widely used to assess the health and nutritional status of children. The aim of the present study was determination of malnutrition and compare estimates of under nutrition among young children under 2 years of age from Birjand city of Iran using WHO growth standard and the National Center for Health Statistics [NCHS] references. The cross-sectional descriptive study conducted on 822 children under 2 years of age mean z scores for weight-for-age and height-for-age and prevalence underweight, stunting and wasting were calculated using the new WHO growth standards and compared with NCHS references. Compared with NCHS reference, the mean height for age were lower and mean weight for age scores were almost similar using the WHO standards. Prevalence underweight, stunting, and wasting using WHO standards were 5.2-8.2% and 1.9%, respectively, compared to 6.5-37.3% and 1% based on the NCHS references. Using WHO standards resulted differences in mean z score for height for age and changes in prevalence of stunting compared with NCHS references in Birjand city children

Prevalence of abdominal obesity in adolescents 2012, birjand, east of Iran

Prevalence of obesity in children has been increased during recent decades all over the world. Obesity, particularly, abdominal obesity [AO] is associated with the risk of metabolic syndrome and cardiovascular disease. This study aimed to assess obesity and central obesity within students aged 11-18 of Birjand city. This cross-sectional and descriptive- analytical study was conducted on 2458 secondary and high school students, including 1345 girls [54.8%] and 1113 boys [45.2%], who had been selected from Birjand Middle and high schools through multiple-cluster sampling in 2012. For determination of AO, waist circumference and the percentage 90 or more regarding age and sex were used. The obtained data were analyzed by using statistical t-tests and X[2] at the significant level P < 0.05. Among the studied students, average 16.3% [20% of boys and 13.2% of girls] had AO. The obtained data about these two groups shows statistical significant difference of P < 0.001. Chance of AO in boys was 1.6 times greater than that of girls. Odds ratio [OR] = 1.6 [confidence interval [CI]: 1.3-2.1]. It was 1.9 times more about under 15-year-old than over 15 aged subjects. OR = 1.9 [CI: 1.5-2.4]. Regarding high prevalence of AO in Birjand adolescents, it is recommended that adolescents and their families should be warned for long-term outcomes of obesity on quality-of-life. Periodic studies are suggested for awareness of obesity trends in the coming years

Prevalence of overweight, obesity and central obesity among elementary school children in Birjand, East of Iran, 2012

Prevalence of obesity in children has been increasing during recent decades all over the world. Obesity, particularly central obesity, is associated with metabolic syndrome and cardiovascular diseases. The present study aimed to assess obesity and central obesity in 6-11 year old Birjand elementary school children, East of Iran. This cross-sectional study was conducted on 1541 elementary school children, i.e. 851girls and 690 boys, selected from Birjand elementary schools through multiple-cluster sampling in 2012. In order to determine overweight and obesity the percentile of CDC was used, so that, 85-95[th] percentile were taken as overweight and >95[th] percentile was defined as obese with respect to age and sex. For determination of central obesity, waist circumference and the >/= 90[th] percentile were used regarding age and sex. The obtained data was analyzed by means of SPSS software [V: 15] using t and chi-square statistical tests at the 0.05 significant level. Out of the studied children, 9.6% [11% of boys and 8.3% of girls] were overweight and 9.2% of children [i.e. 10.9% of boys and 7.9% of girls] were obese. About 15.7% of children [i.e. 20.3% of boys and 12% of girls] had central obesity. Regarding high prevalence of obesity, central obesity, and overweight in Birjand elementary school children, it is recommended that families should be provided with necessary information with respect to correcting life-style and preventing obesity in children